We then performed a separate retrospective analysis of patients with ARDS using University of Chicago patients ( N = 302) as a validation cohort. We first used publicly available databases from the ALTA, EDEN, and OMEGA ARDS Network trials ( N = 124) as a derivation cohort to test our hypothesis. We performed two separate exploratory analyses. We hypothesized that early measurement of the difference between arterial and end-tidal CO 2 (arterial-ET difference), a surrogate for dead space fraction, would predict mortality in mechanically ventilated patients with ARDS.
In acute respiratory distress syndrome (ARDS), dead space fraction has been independently associated with mortality.
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